Advancing the next era of national science

American leadership has always been driven by scientific leadership. The technologies behind economic growth, national security, and better lives—from energy and computing to medicine, aerospace, and advanced manufacturing—begin with the ability to discover, build, and deploy.

Frontier AI can expand that ability. It can help compress decades of scientific progress into years, strengthen the institutions behind American innovation, and give researchers new capacity to solve problems once considered out of reach.

OpenAI is committed to bringing these capabilities to American science. We are working with the U.S. government, National Laboratories, universities, and researchers to connect frontier models with the people, supercomputers, simulations, and facilities that make American science exceptional.

Our goal is to help scientists explore more ideas, test hypotheses faster, and move from insight to validated results more quickly. That requires pairing frontier models with the tools, workflows, expertise, and infrastructure of research environments, turning AI from tool to national strategic scientific infrastructure.

Our commitments

As part of the U.S. Department of Energy’s Genesis Mission⁠(opens in a new window), OpenAI will support participating researchers through broad access, frontier capabilities, technical collaboration, and focused scientific campaigns. We will: 

These commitments build on our work across the national-laboratory system. In an AI Jam Session with nine National Laboratories, more than 1,000 scientists tested frontier models on domain-specific problems and provided structured feedback.

We also deployed advanced reasoning models on Venado, the supercomputer at Los Alamos National Laboratory, as a shared resource across the National Nuclear Security Administration laboratories. This work explores how frontier reasoning can support complex research alongside high-performance computing.